document: Estimation of 3-D left ventricular deformation from medical images using biomechanical models The quantitative estimation of regional cardiac deformation from three-dimensional -LRB- 3-D -RRB- image sequences has important clinical implications for the assessment of viability in the heart wall . We present here a generic methodology for estimating soft tissue deformation which integrates image-derived information with biomechanical models , and apply it to the problem of cardiac deformation estimation . The method is image modality independent . The images are segmented interactively and then initial correspondence is established using a shape-tracking approach . A dense motion field is then estimated using a transversely isotropic , linear-elastic model , which accounts for the muscle fiber directions in the left ventricle . The dense motion field is in turn used to calculate the deformation of the heart wall in terms of strain in cardiac specific directions . The strains obtained using this approach in open-chest dogs before and after coronary occlusion , exhibit a high correlation with strains produced in the same animals using implanted markers . Further , they show good agreement with previously published results in the literature . This proposed method provides quantitative regional 3-D estimates of heart deformation
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